Molecular diagnosis in hypospadias

Hypospadias in goats

Hypospadias is an uncommon congenital defect of urinary tract in farm animals. This defect has been recorded rarely in calves, lambs and foals in the world. The aetiology of hypospadias is not well understood, it seems to be multifactorial and may be related to genetic, endocrinological, and environmental factors. During April to October 2007, twenty-four goat kids with sings of hypospadias wer...

Molecular Diagnosis of Familial Hypercholesterolemia

Abstract Background and objectives: Familial hypercholesterolemia (FH) is an autosomal disorder characterized by increased levels of total cholesterol and low density lipoprotein cholesterol. The FH clinical phenotype has been associated with increased risk of coronary heart disease and premature death. The mutation in LDLR gene in most cases is responsible for FH phenotype. Furthermore, other ...

Application of Molecular DNA Markers (STRs) in Molecular Diagnosis of Down Syndrome in Iran

Down syndrome is one of the most common causes of mental retardation observed in approximately 1/700 live birth. The use of two or more STR markers related to chromosome 21 facilitates the diagnosis of Down syndrome within about six hours from the collection of the samples. This is the first study has been performed in Iranian population to assess the diagnostic value of using small tandem repe...

Molecular diagnosis of Helicobacter pylori in semen of infertile men

Prenatal diagnosis of penoscrotal hypospadias and review of the literature.

Urinary tract abnormalities are frequently detected during obstetrical ultrasonography (US). However, hypospadia is often missed on prenatal US, despite it being the most common congenital defect of the male external genitalia. The prenatal recognition of hypospadias is important because it will alert the physician to order karyotyping and to look for any possible associated dysmorphic syndrome...